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even transient episodes significantly increase the risk of chronic kidney disease (CKD), cardiovascular complications, and long-term mortality (Kellum et al

Int J Mol Sci 23(20):12242

This was not due to RAP treatment, as thiol levels were not altered by RAP treatment in wildtype Pf3D7 parasites (Fig 4D)

Science 349, 1254766

( D ) Newly induced WT Cystinosin-GFP has a prominent 75 kDa ER form before it matures into the 100 kDa lysosome form

The first-line defense mechanism is the most efficient and involves antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)