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Tyrosine kinase inhibitors with inhibitory effects on VEGF prevent tumor angiogenesis, resulting in significant hypoxia in the tumor

Such treatments are employed when restoring B12 levels with supplements, and food is challenging

PMID 16648861

(1996) The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells