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NRF2 regulates cellular redox balance and interacts with pathways such as phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), Notch, hypoxia-inducible factors (HIFs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), myelocytomatosis oncogene (MYC), and forkhead box M1 (FOXM1), promoting tumor progression by enhancing EMT, angiogenesis, and immune evasion (150152)

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Overall, based on the antibiotic susceptibility profile and hemolytic activity in vitro , GXL94 could fulfill the primary requirements of a probiotic and make this strain a safe candidate for further validation in future probiotic studies in vivo

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