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PCa also engages ferroptosis, an iron-dependent death pathway driven by glutathione peroxidase 4 (GPX4) downregulation and lipid peroxidation (202)

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Compr Rev Food Sci Food Saf 21(3):26652687

4.2.3 Difficulty in predicting the structural basis of multicomponent systems in Chinese medicine The multi-component, multi-target, synergistic nature of TCM compounding as a core form of practice makes it particularly challenging for elucidating the precise mechanisms and structural basis underlying its interactions with dynamic biological targets