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This mechanism has been proposed to underlie observations related to tissue matrix integrity noted across multiple research studies

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References Sosne G, Qiu P, Kurpakus-Wheater M

Bioinformatic approaches for the analysis of DNA methylation Although the methodologies described in the previous section enable the detection of differential methylation at single cytosines (DMCs), DNA methylation alterations may also occur across multiple intragenic and intergenic loci, resulting in differentially methylated regions (DMRs)