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This condition is very frequent, reaching a prevalence of approximately 9% in Caucasians (11.6 and 6.1% in males and females, respectively) [151], but differs geographically among various other populations [107]

However, based solely on H&E staining, a diagnosis of sinusoidal cell hypertrophy/karyomegaly is appropriate

The effect of glucocorticoid on auditory function was first reported in the late 1970s, when two synthetic analogues of glucocorticoid (cyclophosphamide and dexamethasone) were used in patients with autoimmune hearing loss, and hearing was substantially improved [121]

Many sufferers therefore rely on vitamins to combat fatigue and get their energy metabolism back on track

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