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Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated Circulating factors

124 In PAECs from Tie2Cre-mediated disruption of Egln1 mice, decreased PHD2 expression leads to HIF-2 upregulation and subsequent release of CXCL12

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The therapeutic impact of irbesartan could be attributed to the decrease in inflammatory factors like interleukin 1 and C-reactive protein, inhibition of vasoconstrictor factors and inflammatory mediator's release, or alteration in specific intestinal flora composition [109]

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Ethics declarations Ethical approval All experimental protocols were conducted in compliance with institutional animal care guidelines and approved by the Institutional Animal Ethics Committee of Huazhong University of Science and Technology (Ethical Approval No