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J Exp Bot 68:17151729 Naranjo-Arcos MA, Maurer F, Meiser J, Pateyron S, Fink-Straube C, Bauer P (2017) Dissection of iron signaling and iron accumulation by overexpression of subgroup Ib bHLH039 protein

This compound has been shown to trigger apoptosis in lung cell lines [498]

Acknowledgments We thank the Mass General Brigham Department of Anesthesiology at Massachusetts General Hospital for their support

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As a regulator in bile acid metabolism, FXR not only affects bile acid synthesis, reabsorption, and excretion [104], but also serves as a protector against ferroptosis