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This is achieved in part through the transcriptional activation of genes such as MMP2 and MMP9, which encode matrix metalloproteinases that degrade extracellular matrix barriers (81), as well as CXCR4, a chemokine receptor important in glioma cell migration along stromal cell-derived factor 1 (SDF-1) gradients

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When Deura utilized IL-6 to culture granulosa tumor cell lines, it could enhance ERK1/2 phosphorylation, limit CYP19 expression, and diminish estrogen release (89)

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Finally, we established the crucial role of mitochondrial CD147 in lactate uptake, oxidation, and stemness maintenance, and developed an intracellularly expressed scFv targeting mitochondrial CD147 that effectively inhibited stemness potentials and metastasis

Neurology 87 , 699708 (2016)