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Under these circumstances, BAP31 is cleaved with consequent formation of the p20 fragment, which activates the mitochondrial apoptotic events such as cytochrome c release, resulting in activation of the intrinsic apoptotic pathway [123, 125]

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Response to treatment was defined as the following within 3 days of initiation: Complete response decrease in Cr to 50% from baseline but not to 110 bpm) had increased rates of hospital readmission compared to those with no readmission or only ED visits (52% vs 14% vs 22%)

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