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To overcome this, present studies are directed towards introducing polymer coatings (e.g., PEGylation) or cell membrane coating technologies (using erythrocyte or cancer cell membranes) to confer immune evasion ( aroA mutant has been shown to paradoxically induce higher TNF- production than its unattenuated counterparts ( 10.3 Environmental shedding and biosafety Attenuated Salmonella are live bacteria and can be released into the tumor microenvironment through patient excretion, with the potential for transmission

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There is only a small amount of other published research on natural agents, including green tea and black cohosh

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