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Moreover, they elucidated that PC dysfunction is the basis of mitochondrial respiratory deficiencies and ciliary-mediated SHH-signaling, which is also a common molecular characteristic of early PD, including sporadicand familial (PINK1, LRRK2) PD (Schmidt et al., 2022)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Krupinski J, Abudawood M, Matou-Nasri S, Al-Baradie R, Petcu EB, Justicia C, Planas A, Liu D, Rovira N, Grau-Slevin M, Secades J, Slevin M, 2012

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These metabolites can give rise to NO following reductive bioactivation and cooperates with tissue-bound storage forms of NO undergoing redox-activation to contribute to overall availability [30]

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