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The protocol typically runs 4-6 weeks with dosing starting higher and tapering down as natural production resumes

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Elevated intracellular Ca 2+ activates Ca 2+ -sensitive Gardos channels (KCa3.1, encoded by KCNN4), resulting in K + efflux, membrane hyperpolarization, Cl loss, and subsequent osmotic cell shrinkage (Qadri et al., 2012

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We further assessed other intracellular antioxidant defenses, including catalase, vitamin E and the master antioxidant response transcription factor Nrf2 (Fig.5)

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