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Protocol [1] Posterior cortex, hippocampus, striatum and liver supernatants of 30-day-old rats are pre-incubated for 30 min at 30C in the presence of L-Tyrosine (Tyr) at final concentrations ranging from 0.1, 1.0, 2.0 or 4.0 mM, and the activities of citrate synthase, malate dehydrogenase and respiratory chain complexes I, II, IIIII and IV are evaluated [1]

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Tyrosine oxidation may also be the result of oxidative stress caused by reactive oxygen and nitrogen species or ultraviolet and visible radiation 10

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Glutathione peroxidase knockout mice have abnormal cardiac mitochondria and associated with increase mitochondrial ROS production and oxidative mtDNA damage