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Therefore, based on their solubility in aqueous environments, the combination of TA and KGN in hydrogels could realize on-demand drug release to sequentially recruit MSCs and stimulate chondrocyte differentiation to accelerate new cartilage formation

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The analysis of B12 in foods is a challenging task due to low concentrations of natural vitamers in non-supplemented foods, chemical instability of cobalamins, and potential presence of a wide range of structural analogs in the matrices [6, 7]