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Detection of leptomeningeal disease using cell-free DNA from cerebrospinal fluid

doi: 10.1080/21655979.2022.2049471 366 ZhangYZhouXLiangGCuiMQiuZXuJet al

Elderly patients tend to have a greater frequency of decreased hepatic, renal, or cardiac function, and also have concomitant disease or receiving other drug therapy

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ACLY is also phosphorylated at this site by protein kinase A (PKA), which significantly increases ACLY enzyme activity (6-fold increase in V max compared to that of nonphosphorylated ACLY) 93

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