ethanol metabolism depletes glutathione metabolism: The good, the bad, and the ugly Frontiers | Excessive alcohol consumption:

Supporting this mechanism, Qiu et al

3 Potential molecular targets for neurotherapeutics to mitigate Mns neurotoxicity Dysregulations of Mn-induced cellular processes are associated with altering Mns target genes at the molecular and transcriptional levels

[30] and Hasosah et al

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The mitochondrial GSH pool is maintained in the reduced state by GR that couples GSSG reduction to the matrix NADP+/NADPH pool (Figure 3) [3,23]

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