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When your 40 trillion cells can't process environmental and metabolic demands efficiently, both chemical sensitivity and MTHFR-related symptoms emerge from the same overwhelmed cellular systems

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[146] Dependence and withdrawal Drug tolerance develops rapidly in amphetamine abuse (i.e., recreational amphetamine use), so periods of extended abuse require increasingly larger doses of the drug in order to achieve the same effect

From a mechanistic perspective, herbal antidepressants frequently modulate monoaminergic systems by either inhibiting MAO-A/B or augmenting the availability of serotonin, norepinephrine, and dopamine