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JNJ-7706621 forms three H-bonds with the hinge through its central amino-triazole group, instead of two in the case of PRT062607-related compounds

Key examples include: Statins: Lovastatin**: 15-fold AUC increase with grapefruit juice consumption16 Atorvastatin 2.5-fold increase in AUC for atorvastatin acid4 3.3-fold increase for atorvastatin lactone4 Simvastatin: Over 10-fold AUC increase with repeated high-quantity consumption 2 Likes Joseph_Lavelle March 17, 2025, 3:49pm #6 YesIt would increase the AUC by increasing the starting amount but not by increasing the half-life (which is what I thought you meant)

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