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CAR T cell therapy for B-cell lymphomas

Even if a fraction of the active ingredient reaches the small intestine intact, its absorption is often severely restricted due to unfavorable molecular size, poor intestinal permeability, and extensive hepatic first-pass metabolism

10.1016/j.ghir.2007.08.005

229,230 The leading response of astrocytes to infectious agents is reactive astrogliosis, which erects parenchymal barriers and encapsulates brain abscesses, thus preventing infection spread