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Intriguingly, the glutamine-dependent checkpoint at late G1 phase in the cell cycle is dysregulated in K-Ras-driven cancer cells 185

[DOI] [PubMed] [Google Scholar] 44.Codagnone M.G., Podest M.F., Uccelli N.A., Reins A

S.DuckworthK.FoxworthP.FulwiderT.SuthoffE

Selenium deficiency as a possible factor in the pathogenesis of myxoedematous endemic cretinism

Although, cells physiologically produce a certain amount of ROS (e.g.: respiratory chain in mitochondria), excessive production has the potential to significantly damage cell homeostasis, mainly through oxidative modifications of DNA/RNA and proteins