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doi: 10.1126/science.aao4227 74 AudritoVManagoAGaudinoFSorciLMessanaVGRaffaelliNet al

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The results showed that inhibiting HDAC5 significantly increased CD8 + T cell infiltration in the tumor microenvironment, reduced the proportion of Tregs, and exhibited synergistic effects with anti-PD-1 antibodies, jointly inhibiting tumor growth (69)