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In neuronal senescence model studies, the active ingredient of the product can cross the blood-brain barrier (and act directly on neurons in vitro), increase NAD+ levels in nerve cells, protect mitochondrial function, reduce neuronal apoptosis, and promote the synthesis and release of neurotransmitters (such as dopamine and acetylcholine), thereby improving signal transduction in nerve cells

Search strategies were employed using all major peer-reviewed literature databases, including PubMed, Web of Science, Scopus, Science Direct, and Google Scholar

Eur J Biochem 270(3):404414

Nevertheless, it was earlier reported that it is also associated with bleeding upon its parenteral administration

Both Protandim and placebo groups experienced a similar drop in serum TBARS post-exercise after 90 days of supplementation