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Finally, in order to investigate whether GMP inhibited p300/GATA4-dependent transcriptional activation, reporter gene assays were performed with HEK293T cells, using ANF and ET-1 promoter-luciferase constructs

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This separation of activities is pharmacologically significant: the primary safety concerns with using GH for weight management are insulin resistance and IGF-1 elevation

High root-zone temperature (HT) may negatively affect plant physiology, morphology and growth 9,10