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[PubMed: 1997210] 107

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However, in cultures of the SEV group, the reduction of CCL3 by B12 did not reach statistical significance and intracellular IL-1B levels were very low, close to the detection limit of the technique, suggesting that, in severe COVID-19, leukocytes are more prone to promptly export IL-1B

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Mechanisms investigated Metabolic-pathway research converges on a small set of enzymatic and receptor targets, and these compounds map onto different ones they are not interchangeable: NNMT inhibition (5-Amino-1MQ): studied as a small-molecule inhibitor of nicotinamide N-methyltransferase, an enzyme implicated in cellular NAD/SAM metabolism

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