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[1] Serotonin is a neurotransmitter involved in several functions, including the regulation of mood, appetite, sleep, and stress response

Chronic ER stress, resulting from impaired ERAD, triggers the UPR, which, if unresolved, can lead to cardiomyocyte apoptosis and heart failure

Valko, M., Izakovic, M., Mazur, M., Rhodes, C.J., Telser, J

D., McDonough J

doi: 10.1038/s41380-022-01456-3 173 MckernanD

Increased formation of ROS in mitochondria is a typical phenomenon in diabetic patients with cardiovascular diseases, typically with left ventricular hypertrophy and diastolic dysfunction (Jeong et al