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This high rate of RCD may serve a few biological functions including brain tissue morphogenesis, synaptic connection optimization, cell number regulation, and elimination of developmentally obsolete structures (130, 131)

Some limitations with this study include the use of only male rats and lack of assessment of the number and morphology of mitochondria in the brain (Reference Sindhu, Binitha, Nair, Maliakel, Ramadasan and Krishnakumar66)

This article is based on previously conducted studies and does not contain any new studies performed by any of the authors in human participants or animals

Updated March 7, 2018

73 Notably, VSMC-specific EP4 knockout increases vascular inflammation and leads to vascular remodeling and elevated blood pressure