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Variants in MTHFR, MTRR, and COMT shape baseline methylation and B12 metabolism, the pathways MIC-B12 acts on

Lei et al., 2022), indicating the deficiency of EpCAM leads to the breakdown of the intestinal immune homeostasis

The simpler same-day approach wins for most people purely because it is easier to remember, and consistency beats cleverness when the whole protocol depends on you taking the doses