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these reviews have noted that Mn-dependent mitochondrial redox control is a possible mechanistic link between Mn status and disease vulnerability 10 and have summarized how chemical tools for tracking Mn have helped map its subcellular localization, speciation, and dynamics 11

This approach not only offers an alternative interpretation of the pathogenic mechanisms underlying specific targets but also expands the scope of druggable target screening by introducing novel biological phenotypes

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10.1016/S2665-9913(20)30164-8 94 HuiQ.AmmeterE.LiuS.YangR.LuP.LahayeL.et al (2020)