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These recommendations consider the main clinical targets in PCOS (insulin resistance, lipid imbalance, hormonal dysfunction), the most effective dosages and durations, and the current level of supporting evidence

Decreased levels of glutathione and elevated oxidative stress markers were observed in both siRNA (Fig

The expression of the VD metabolism genes CYP2R1 and CYP27A1 (25-hydroxylase), CYP27B1 (1--hydroxylase), and vitamin D receptor (VDR) were downregulated in the livers of mice fed an HFD (GSH- deficient) compared with control diet-fed group

Innovation in this field is advancing towards precision engineering, exemplified by a novel GLP-1-estrogen conjugate that, in preclinical models, delivered targeted metabolic improvements while avoiding systemic reproductive toxicity [30]