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This result is interesting in two aspects: first, it provides further evidence of increased DNA DSB abundance in motor neurons of Wobbler mice and confirms the overexpression of H2ax at the mRNA level and increased H2ax fluorescence signal intensity in spinal cord sections of Wobbler mice

Motzer RJ, Tannir NM, and McDermott DF, et al (2018) Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma N Engl J Med 378 (14) 12771290 PMID: 29562145 PMCID: 5972549 8

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It is worth mentioning that HO-1 exhibits the most significant diagnostic efficacy in discerning between benign and malignant cystic fluid, indicating a robust correlation between REDOX imbalance and the malignant progression of endometriosis (49)

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