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Authors' contributions MR and KK performed the subject identification, clinical evaluations and coordinated the follow-ups of the subjects

The accumulation of Akkermansia promotes intestinal mucosal barrier damage and gut inflammation, facilitating abnormal -syn aggregation within the intestine, which can ultimately lead to systemic inflammation [89]

In renal cells of DKO mice(GSTT1/GSTM1-DKO), cisplatin-induced nephrotoxicity is primarily mediated through oxidative stress and ferroptosis pathways, with Fer-1 acting as a ferroptosis inhibitor and NAC as an antioxidant, effectively alleviating damage caused by these mechanisms (6062)

The flow cytometry analysis showed that, for an effective siRNA concentration of 8 nM, the eGFP expression was reduced by 35%

A combination of methods (e.g