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Institutional review board statement The animal experiment was approved by The Institutional Animal Care and Use Committee (IACUC) of Beijing Vital River Laboratory Animal Technology Co., Ltd., (No.PA23072602)

Results FA excess or B 12 deficiency delays the generation and/or migration of cortical upper layer projections neurons To test the effects of gestational maternal folate/B 12 intake on the offspring, we created five nutritional groups of C57BL/6NJ dams that were fed amino acid defined rodent chow (Dyets Inc., Bethlehem, PA): (1) control, (2) high FA, (3) low B 12 , (4) high FA/low B 12 , and (5) high 5-FTHF

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The presence of the reducing agents will break disulfide bonds between cysteines

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Another trial compared Prolia to a drug called risedronate