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Lysosomal damage pathway: Upon phagocytosis by macrophages, crystals cause lysosomal membrane rupture, releasing cathepsin B, which activates the NLRP3 inflammasome (Kluck et al., 2021

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Persistent cellular damage provokes an inflammatory response that recruits innate immune cells (particularly macrophages) to the site of injury and elicits the release of pro-fibrotic factors, such as transforming growth factor (TGF-) and -smooth muscle actin (-SMA) [13]

doi:10.4103/0975-3583.102694 Li, Na et al

In this review, we describe the metabolic transformation in cancer cells, then summarize different roles of glutamine in cancer metabolism in biosynthesis and stress protection

However, Hara et al