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Description

Nature 543 , 248251 (2017)

Such redox-active disulfides have been shown to be important for normal cellular function, with perturbations postulated to be involved in pathological conditions that are characterized by abnormal/altered redox states, including ageing, cardiovascular disease, some cancers, asthma, rheumatoid arthritis, cystic fibrosis and multiple neurodegenerative diseases (e.g., Alzheimers, Parkinsons, Huntingtons, Creutzfeldt-Jakob disease) 7