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Eur J Clin Nutr 72, 105111.CrossRefGoogle ScholarPubMed Gandek, TB, van der Koog, L & Nagelkerke, A (2023) A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles

When donating an electron, glutathione itself becomes reactive and readily reacts with another reactive glutathione to form GSSG

However, cysteine has been shown to accumulate in tissues of patients with glutathione synthetase deficiency at least in cultured fibroblasts [24]

doi: 10.1172/jci.insight.123182 172 LiuZ.RenZ.ZhangJ.ChuangC.-C.KandaswamyE.ZhouT.et al

In that study, the plasma glutathione levels increased to 300% of baseline levels after one hour, followed by a decrease to approximately 200% of baseline levels within the next three hours