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Moreover, animal studies have shown that complete inhibition of BACE1 activity results in an elimination of A in neurons, but A is required for certain physiological neuronal functions such as regulation of neuron-glia signaling by enhancing spontaneous astrocyte calcium transient signaling via 7-nAChRs (Lee et al., 2014), activation of M2 microglia cells after SCI promoting plasticity, axonal outgrowth and inhibition of inflammation (Kigerl et al., 2009