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Larsen MK, Skov V, Kjr L, Eickhardt-Dalbge CS, Knudsen TA, Kristiansen MH, et al

89 This occurs through hypoxia-mediated suppression of matrix mineralization-related enzymes, as well as reduced expression and activity of alkaline phosphatase

The full effect may take 8 weeks or longer

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Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus

Primer sequences for target genes are commercially synthesized by Qingke Biotech (Beijing, China) with detailed specifications provided in Table 1