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Journal of Thoracic and Cardiovascular Surgery 169: e17, 2025

Using rectal administration to achieve systemic activity is preferred when the drug is destroyed in the GI tract, if oral administration is not possible because of vomiting, or the patient is unconscious or incapable of swallowing oral formulations

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Although in clinical trials Ipamorelin is often well tolerated and is considered to have a positive safety profile, common side effects of Ipamorelin peptide may include mild irritation or redness at the injection site, headaches, and increased hunger or appetite