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The lack of standardized doseresponse studies makes it difficult to determine whether findings from basic science research hold clinical significance

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2001;85(1):F70-2

The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb) for the placebo group which was statistically significant

In the LRH cohort, it reached a peak concentration of 496 34.4 pg/mL by day 5, versus 304 49.4 pg/mL for B-SUB B12