acetaminophen overdose napqi glutathione mechanism authoritative source The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets What is the antidote of

What is the antidote of choice for acetaminophen poisoning? N acetylcysteine (NAC) Glutathione Answer in the story Acetaminophen metabolism. Acetaminophen is metabolized primarily by sulfation and glucuronidation. However, it can also be oxidized by CYPs to form NAPQI. NAPQI can then interact with cellular macromolecules, resulting in toxicity, or it can be detoxified How acetaminophen is metabolized in the liver A quantum chemical study of the reactivity of acetaminophen (paracetamol) toxic metabolite N acetyl p benzoquinone imine with deoxyguanosine and glutathione ScienceDirect How a common drug causes liver failure EurekAlert! Acetaminophen MSK Medbullets Step 1

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