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Lower tirzepatide doses (510mg weekly) reduce GI side effect burden while still providing meaningful appetite suppression, allowing researchers to maintain protocol adherence without the nausea and vomiting that causes 1015% of subjects to discontinue at higher doses

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Daratumumab and nanobody-based heavy chain antibodies inhibit the ADPR cyclase but not the NAD (+) hydrolase activity of CD38-expressing multiple myeloma cells