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5 Glutathione peroxidase mimetics The main function of the enzyme glutathione peroxidase (GPx) is the elimination of hydrogen peroxide (see Figure 5

J Psychopharmacol (Oxf) 23:346388

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Indeed, a burst in H 2 O 2 production in mitochondria may be required to feedback and deactivate Odh and possibly Pdh to curtail further H 2 O 2 production by either Odh and Pdh or the respiratory complexes (Figure 2) (Young et al., 2000

In studies of haematopoietic cancers, reduced risk of disease recurrence was noted among children with acute lymphoblastic leukaemia, who had alleles encoding no or lower activity for GSTT1, -M1 and -P1 (Stanulla et al, 2000)