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Epi-nutrients as epigenetic enzyme cofactors In addition to functioning as substrates, nutrients also serve as vital cofactors that assist various enzymes in catalyzing epigenetic processes, further illustrating the complex role of nutrition in regulating gene expression (Donohoe and Bultman 2012)

In inactive (closed) chromatin, silenced genes are suspected to be present (Lai et al., 2018)

Recently, emerging evidence has identified ferroptosis, an iron-dependent regulated cell death, as a pivotal factor in driving PD pathogenesis, with close associations to key mechanisms including -syn protein aggregation, excessive oxidative stress, mitochondrial dysfunction, disturbances in iron metabolism, and activation of neuroinflammatory responses

10.1016/j.neuroscience.2017.07.055 22

Eating foods rich in any of these can increase glutathione production

It has been found that, in otherwise healthy HIV infected humans, the intracellular GSH levels in the peripheral blood mononucleocytes (PBMs) was significantly increased after oral administration of stabilized GSH