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30 Also, the onset of acute pancreatitis occurred after 12 months in the LEADER trial and after more than five to six months in the SCALE trial, indicating that the likelihood of developing pancreatitis was influenced more by the rate and degree of weight loss than the drug itself

Endocrinology (1997) 138:28718

Mechanistically, they enhance anti-proliferative and anti-inflammatory activities, induce cell cycle arrest (G2/M phase), promote cell apoptosis, and modulate the activity of proteins such as P-gp and acetylcholinesterase [941,942,943]