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217 , jem.20190489 (2020)

Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation

D-gal: D-galactosamine

Augmented IOP exhibits direct physical and biochemical stress on RGCs: (i) decreased axonal transport leading to the nutritional deprivation of neurotrophic factors, (ii) tissue hypoxia at the optic nerve head resulting in cellular oxidative stress, (iii) glial cell activation inducing the degradation and remodeling of extracellular matrix invoking biomechanical stress on RGCs, and (iv) TNF--mediated RGC damage [19,20,21,22]