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Furthermore, statins can remarkably enhance cellular communication network factor 3 (CCN3) expression, prevent expression of pro-inflammatory VCAM-1 cell adhesion molecule, and inhibit monocyte adherence to endothelial cells through the KLF-2 transcription factor pathway, lowering endothelial inflammation [65]

Data demonstrates that the neurologic effects of DON are partially dependent on DONs direct action on brain cells, even though some of these modifications may be related to peripheral effects (Figure 1)

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doi:10.7326/0003-4819-137-12-200212170-00007

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Face-to-face clinics have largely been replaced by remote consultations (via telephone or video call), with reduced capacity for endoscopic investigations and elective surgeries