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A meta-analysis of 7 RCTs, including 660 patients with HE grade ranging from subclinical to grade 3, found l-Carnitine to reduce ammonia levels, with associated improvement in HE [98]

Screening tools such as the Brief Fatigue Inventory (BFI) can help quantify symptom burden and guide interventions

In ovarian cancer, C-MYC was shown to directly bind and downregulate NCOA4 mRNA, thereby inhibiting ferritin autophagy and ferroptosis, reducing ROS production, blocking mitophagy, and finally promoting tumor proliferation, invasion, immune evasion, and tumorigenesis through suppression of HMGB1 release (183)