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Reactive oxygen species: From health to disease

10.3390/ijms140917410 [DOI] [PMC free article] [PubMed] [Google Scholar] Steyfkens F., Zhang Z., Van Zeebroeck G., Thevelein J

Chuang TY, Wu HL, Min J, Diamond M, Azziz R, Chen YH

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A prospective randomized controlled open trial of 75 breast cancer patients showed that oral NAC (1200 mg once and twice daily) was effective in reducing the incidence and severity of paclitaxel-induced peripheral neuropathy, accompanied by increased serum nerve growth factor (NGF) levels and decreased malondialdehyde (MDA) levels, which could prevent grade 3 neurotoxicity [68]