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in the absence of validated data, a conservative approach is appropriate discard sooner rather than later if there is any doubt Lyophilised (unreconstituted) vials should be stored according to the supplier's or trial protocol's instructions

Bibliography Smith AD, Refsum H

Pharmacokinetic modeling and clinical experience support this approach, though no head-to-head randomized trial has compared 1.5 mg twice weekly versus 2.5 mg once weekly

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